The actiopathogenesis of leucocytoclastic vasculitis is still unknown, but recently hepatitis C virus (HCV) has been suggested as trigger of autoimmunity. We report a case of a 26-yr-old patient with purpura due to leucocytoclastic vasculitis associated with hepatitis C virus infection. Laboratory findings showed AST, ALT, gamma GT within normal limits, positive antibodies to HCV (IIF and Riba II) and polymerase chain reaction for HCV RNA. Anti-nuclear antibodies, IgG and IgM anti-cardiolipin antibodies, anti-platelet antibodies and anti-neutrophil cytoplasmic antibodies with perinuclear pattern were also present. A skin biopsy specimen of a purpuric lesion showed leucocytoclastic vasculitis with small vessel thrombosis and perivascular deposition of IgM and fibrinogen on immunofluorescence study. This case shows a role of HCV in leucocytoclastic vasculitis; it is possible that this HCV can induce autoimmunity independently of cryoglobulins and liver involvement.

Manna, R., Todaro, L., Latteri, M., Gambassi, G., Massi, G., Grillo, M., Romito, A., Caputo, S., Gasbarrini, G. B., Leucocytoclastic vasculitis associated with hepatitis C virus antibodies, <<BRITISH JOURNAL OF RHEUMATOLOGY>>, 1997; 36 (1): 124-125 [http://hdl.handle.net/10807/37492]

Leucocytoclastic vasculitis associated with hepatitis C virus antibodies

Manna, Raffaele;Gambassi, Giovanni;Massi, Guido;Caputo, Salvatore;Gasbarrini, Giovanni Battista
1997

Abstract

The actiopathogenesis of leucocytoclastic vasculitis is still unknown, but recently hepatitis C virus (HCV) has been suggested as trigger of autoimmunity. We report a case of a 26-yr-old patient with purpura due to leucocytoclastic vasculitis associated with hepatitis C virus infection. Laboratory findings showed AST, ALT, gamma GT within normal limits, positive antibodies to HCV (IIF and Riba II) and polymerase chain reaction for HCV RNA. Anti-nuclear antibodies, IgG and IgM anti-cardiolipin antibodies, anti-platelet antibodies and anti-neutrophil cytoplasmic antibodies with perinuclear pattern were also present. A skin biopsy specimen of a purpuric lesion showed leucocytoclastic vasculitis with small vessel thrombosis and perivascular deposition of IgM and fibrinogen on immunofluorescence study. This case shows a role of HCV in leucocytoclastic vasculitis; it is possible that this HCV can induce autoimmunity independently of cryoglobulins and liver involvement.
1997
Inglese
Manna, R., Todaro, L., Latteri, M., Gambassi, G., Massi, G., Grillo, M., Romito, A., Caputo, S., Gasbarrini, G. B., Leucocytoclastic vasculitis associated with hepatitis C virus antibodies, <<BRITISH JOURNAL OF RHEUMATOLOGY>>, 1997; 36 (1): 124-125 [http://hdl.handle.net/10807/37492]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/37492
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