In this study, we investigated the prognostic value of metastasis tumor antigen 1 expression in 81 untreated patients with ovarian cancer. The expression of metastasis tumor antigen 1 was evaluated by immunohistochemistry, and staining was analyzed in relation to clinicopathologic variables, disease-free survival, and overall survival. High expression of metastasis tumor antigen 1 was found to be associated with advanced stage (I/II versus III/IV, P = .02) and with worse response to first-line treatment (P = .03). Cases with high metastasis tumor antigen 1 expression showed a lower disease-free survival compared with cases with low expression (P = .02). In multivariate analysis of disease-free survival, metastasis tumor antigen 1 overexpression retained an independent negative prognostic role (P = .04), when considered together with histotype, stage of disease, residual tumor at surgery, and chemosensitivity. The evaluation of the prognostic relevance of metastasis tumor antigen 1 in late-stage disease showed that overexpression was a prognostic factor for poor disease-free survival and overall survival in this subset of patients, in both univariate and multivariate models. These findings indicate that metastasis tumor antigen 1 overexpression can be used as a predictor of clinical outcome in patients with ovarian cancer and therefore may represent a new prognostic marker.

Prisco, M., Zannoni, G. F., De Stefano, I., Vellone, V., Tortorella, L., Fagotti, A., Mereu, L., Scambia, G., Gallo Guido, D., Prognostic role of metastasis tumor antigen 1 in patients with ovarian cancer: a clinical study, <<HUMAN PATHOLOGY>>, 2011; 43 (2): 282-288. [doi:10.1016/j.humpath.2011.05.002] [http://hdl.handle.net/10807/3734]

Prognostic role of metastasis tumor antigen 1 in patients with ovarian cancer: a clinical study

Zannoni, Gian Franco;Fagotti, Anna;Scambia, Giovanni;Gallo Guido, Daniela
2012

Abstract

In this study, we investigated the prognostic value of metastasis tumor antigen 1 expression in 81 untreated patients with ovarian cancer. The expression of metastasis tumor antigen 1 was evaluated by immunohistochemistry, and staining was analyzed in relation to clinicopathologic variables, disease-free survival, and overall survival. High expression of metastasis tumor antigen 1 was found to be associated with advanced stage (I/II versus III/IV, P = .02) and with worse response to first-line treatment (P = .03). Cases with high metastasis tumor antigen 1 expression showed a lower disease-free survival compared with cases with low expression (P = .02). In multivariate analysis of disease-free survival, metastasis tumor antigen 1 overexpression retained an independent negative prognostic role (P = .04), when considered together with histotype, stage of disease, residual tumor at surgery, and chemosensitivity. The evaluation of the prognostic relevance of metastasis tumor antigen 1 in late-stage disease showed that overexpression was a prognostic factor for poor disease-free survival and overall survival in this subset of patients, in both univariate and multivariate models. These findings indicate that metastasis tumor antigen 1 overexpression can be used as a predictor of clinical outcome in patients with ovarian cancer and therefore may represent a new prognostic marker.
2012
Inglese
Prisco, M., Zannoni, G. F., De Stefano, I., Vellone, V., Tortorella, L., Fagotti, A., Mereu, L., Scambia, G., Gallo Guido, D., Prognostic role of metastasis tumor antigen 1 in patients with ovarian cancer: a clinical study, <<HUMAN PATHOLOGY>>, 2011; 43 (2): 282-288. [doi:10.1016/j.humpath.2011.05.002] [http://hdl.handle.net/10807/3734]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/3734
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