Previous studies reported an epidemiological association between CagA-positive H. pylori strains and pre-eclampsia. As antibodies anti-CagA cross-react with endothelial cells and trophoblast cells show an endothelial phenotypic profile, we hypothesized that anti-CagA antibodies may recognize antigens of cytotrophoblast cells, thus impairing their function.
Franceschi, F., Di Simone, N., D'Ippolito, S., Castellani, R., Di Nicuolo, F., Gasbarrini, G. B., Yamaoka, Y., Todros, T., Scambia, G., Gasbarrini, A., Antibodies anti-caga cross-react with trophoblast cells: a risk factor for pre-eclampsia?, <<HELICOBACTER>>, 2012; 17 (6): 426-434. [doi:10.1111/j.1523-5378.2012.00966.x] [http://hdl.handle.net/10807/36210]
Antibodies anti-caga cross-react with trophoblast cells: a risk factor for pre-eclampsia?
Franceschi, Francesco;Di Simone, Nicoletta;D'Ippolito, Silvia;Castellani, Roberta;Di Nicuolo, Fiorella;Gasbarrini, Giovanni Battista;Scambia, Giovanni;Gasbarrini, Antonio
2012
Abstract
Previous studies reported an epidemiological association between CagA-positive H. pylori strains and pre-eclampsia. As antibodies anti-CagA cross-react with endothelial cells and trophoblast cells show an endothelial phenotypic profile, we hypothesized that anti-CagA antibodies may recognize antigens of cytotrophoblast cells, thus impairing their function.
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