We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.

Hohaus, S., Giachelia, M., Massini, G., Vannata, B., Criscuolo, M., Martini, M., D'Alo', F., Voso, M. T., Larocca, L. M., Leone, G., Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma, <<LEUKEMIA RESEARCH>>, 2009; 33 (10): 1352-1356. [doi:10.1016/j.leukres.2009.01.009] [http://hdl.handle.net/10807/26201]

Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma

Hohaus, Stefan;Giachelia, Manuela;Massini, Giuseppina;Vannata, Barbara;Criscuolo, Marianna;Martini, Maurizio;D'Alo', Francesco;Voso, Maria Teresa;Larocca, Luigi Maria;Leone, Giuseppe
2009

Abstract

We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.
2009
Inglese
Hohaus, S., Giachelia, M., Massini, G., Vannata, B., Criscuolo, M., Martini, M., D'Alo', F., Voso, M. T., Larocca, L. M., Leone, G., Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma, <<LEUKEMIA RESEARCH>>, 2009; 33 (10): 1352-1356. [doi:10.1016/j.leukres.2009.01.009] [http://hdl.handle.net/10807/26201]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/26201
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