In patients with chronic congenital haemolytic disorders, human Parvovirus B19 (HPV B19) is frequently involved in pure red-cell aplastic crises. Furthermore, it may inhibit three-lineage haematopoiesis in the bone marrow, causing severe pancytopenia. In such patients, Epstein Barr virus (EBV) infection also seems to share the same mechanism as HPV B19 in inducing bone marrow aplasia, but at present the clinical effect of an infection sustained by both viruses is unknown.
Cefalo, M. G., Maurizi, P., Arlotta, A., Russo, I., Sani, I., Battista, A., Mastrangelo, S., Ruggiero, A., Riccardi, R., Human parvovirus B 19 and Epstein-Barr virus co-infection in a child with hereditary spherocytosis, <<EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES>>, 2012; 16 (2): 265-269 [http://hdl.handle.net/10807/23231]
Human parvovirus B 19 and Epstein-Barr virus co-infection in a child with hereditary spherocytosis
Cefalo, Maria Giuseppina;Maurizi, Palma;Russo, Ida;Sani, Ilaria;Mastrangelo, Stefano;Ruggiero, Antonio;Riccardi, Riccardo
2012
Abstract
In patients with chronic congenital haemolytic disorders, human Parvovirus B19 (HPV B19) is frequently involved in pure red-cell aplastic crises. Furthermore, it may inhibit three-lineage haematopoiesis in the bone marrow, causing severe pancytopenia. In such patients, Epstein Barr virus (EBV) infection also seems to share the same mechanism as HPV B19 in inducing bone marrow aplasia, but at present the clinical effect of an infection sustained by both viruses is unknown.
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