Objective: Multifocal motor neuropathy (MMN) is a rare inflammatory neuropathy, clinically characterized by exclusive motor involvement. We wished to evaluate the possible presence of sensory dysfunction, including the evaluation of small fibres, after a long-term disease course. Patients and methods: seven MMN patients, regularly followed in our Neurology Department, underwent clinical evaluation, neurophysiological examination by nerve conduction studies (NCSs), and Sudoscan. We compared neurophysiological data with a group of patients with other disorders of the peripheral nervous system. Results: NCSs showed a reduction of sensory nerve action potential amplitude in 2/7 MMN patients. Sudoscan showed borderline electrochemical skin conductance (ESC) values in 3/7 MMN patients (two of them with abnormal sensory NCSs). Conclusions: Our results confirm that sensory involvement may be found in some MMN after a long-term disease course, and it could also involve the small fibres.

Luigetti, M., Giovannini, S., Romano, A., Bisogni, G., Barbato, F., Paolantonio, A. D., Servidei, S., Granata, G., Sabatelli, M., Small fibre involvement in multifocal motor neuropathy explored with sudoscan: a single-centre experience, <<DIAGNOSTICS>>, 2020; 10 (10): N/A-N/A. [doi:10.3390/diagnostics10100755] [http://hdl.handle.net/10807/161972]

Small fibre involvement in multifocal motor neuropathy explored with sudoscan: a single-centre experience

Luigetti, Marco;Giovannini, Silvia;Romano, Angela;Barbato, Francesco;Servidei, Serenella;Granata, Giuseppe;Sabatelli, Mario
2020

Abstract

Objective: Multifocal motor neuropathy (MMN) is a rare inflammatory neuropathy, clinically characterized by exclusive motor involvement. We wished to evaluate the possible presence of sensory dysfunction, including the evaluation of small fibres, after a long-term disease course. Patients and methods: seven MMN patients, regularly followed in our Neurology Department, underwent clinical evaluation, neurophysiological examination by nerve conduction studies (NCSs), and Sudoscan. We compared neurophysiological data with a group of patients with other disorders of the peripheral nervous system. Results: NCSs showed a reduction of sensory nerve action potential amplitude in 2/7 MMN patients. Sudoscan showed borderline electrochemical skin conductance (ESC) values in 3/7 MMN patients (two of them with abnormal sensory NCSs). Conclusions: Our results confirm that sensory involvement may be found in some MMN after a long-term disease course, and it could also involve the small fibres.
2020
Inglese
Luigetti, M., Giovannini, S., Romano, A., Bisogni, G., Barbato, F., Paolantonio, A. D., Servidei, S., Granata, G., Sabatelli, M., Small fibre involvement in multifocal motor neuropathy explored with sudoscan: a single-centre experience, <<DIAGNOSTICS>>, 2020; 10 (10): N/A-N/A. [doi:10.3390/diagnostics10100755] [http://hdl.handle.net/10807/161972]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/161972
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact