During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation of the elimination pathways. In this article, we analyse the main pharmacokinetic aspects (absorption, distribution, metabolism and excretion) that exist during the neonatal period, to offer a description of the physiological background for variability in pharmacological dosing.

Ruggiero, A., Ariano, A., Triarico, S., Capozza, M. A., Ferrara, P., Attina', G., Neonatal pharmacology and clinical implications, <<DRUGS IN CONTEXT>>, 2019; 8 (N/A): N/A-N/A. [doi:10.7573/dic.212608] [http://hdl.handle.net/10807/147837]

Neonatal pharmacology and clinical implications

Ruggiero, Antonio
Primo
;
Capozza, Michele Antonio;Ferrara, Pietro
Penultimo
;
Attina', Giorgio
Ultimo
2019

Abstract

During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation of the elimination pathways. In this article, we analyse the main pharmacokinetic aspects (absorption, distribution, metabolism and excretion) that exist during the neonatal period, to offer a description of the physiological background for variability in pharmacological dosing.
2019
Inglese
Ruggiero, A., Ariano, A., Triarico, S., Capozza, M. A., Ferrara, P., Attina', G., Neonatal pharmacology and clinical implications, <<DRUGS IN CONTEXT>>, 2019; 8 (N/A): N/A-N/A. [doi:10.7573/dic.212608] [http://hdl.handle.net/10807/147837]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/147837
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 17
  • ???jsp.display-item.citation.isi??? ND
social impact