The recently introduced monoclonal V600E antibody (clone VE1) is likely to be an alternative strategy for detecting this mutation in thyroid lesions. Although VE1 immunostaining and molecular methods used to assess papillary thyroid carcinoma in surgical specimens are in good agreement, evaluation of VE1 in cytology and cell block samples is rarely performed, and its diagnostic value in cytology has not been well established. In this study, we sought to determine if VE1 is suitable for FNA and cell block method.
Straccia, P., Brunelli, C., Rossi, E. D., Lanza, P., Martini, M., Musarra, T., Lombardi, C. P., Pontecorvi, A., Fadda, G., The immunocytochemical expression of VE-1 (BRAF V600E-related) antibody identifies the aggressive variants of papillary thyroid carcinoma on liquid-based cytology, <<CYTOPATHOLOGY>>, 2019; (Marzo): 1-23. [doi:10.1111/cyt.12690] [http://hdl.handle.net/10807/132558]
The immunocytochemical expression of VE-1 (BRAF V600E-related) antibody identifies the aggressive variants of papillary thyroid carcinoma on liquid-based cytology
Straccia, PatriziaPrimo
;Brunelli, ChiaraSecondo
;Martini, Maurizio;Musarra, Teresa;Lombardi, Celestino Pio;Pontecorvi, AlfredoPenultimo
;Fadda, GuidoUltimo
2019
Abstract
The recently introduced monoclonal V600E antibody (clone VE1) is likely to be an alternative strategy for detecting this mutation in thyroid lesions. Although VE1 immunostaining and molecular methods used to assess papillary thyroid carcinoma in surgical specimens are in good agreement, evaluation of VE1 in cytology and cell block samples is rarely performed, and its diagnostic value in cytology has not been well established. In this study, we sought to determine if VE1 is suitable for FNA and cell block method.
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