The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ∼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.

Utsunomiya, Y. T., Milanesi, M., Utsunomiya, A. T. H., Torrecilha, R. B. P., Kim, E., Costa, M. S., Aguiar, T. S., Schroeder, S., Do Carmo, A. S., Carvalheiro, R., Neves, H. H. R., Padula, R. C. M., Sussai, T. S., Zavarez, L. B., Cipriano, R. S., Caminhas, M. M. T., Hambrecht, G., Colli, L., Eufemi, E., Ajmone Marsan, P., Cesana, D., Sannazaro, M., Buora, M., Morgante, M., Liu, G., Bickhart, D., Van Tassell, C. P., Sölkner, J., Sonstegard, T. S., Garcia, J. F., A PLAG1 mutation contributed to stature recovery in modern cattle, <<SCIENTIFIC REPORTS>>, 2017; 7 (1): 17140-N/A. [doi:10.1038/s41598-017-17127-1] [http://hdl.handle.net/10807/116042]

A PLAG1 mutation contributed to stature recovery in modern cattle

Colli, Licia;Eufemi, Elisa;Ajmone Marsan, Paolo;Sannazaro, Marco;
2017

Abstract

The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ∼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.
2017
Inglese
Utsunomiya, Y. T., Milanesi, M., Utsunomiya, A. T. H., Torrecilha, R. B. P., Kim, E., Costa, M. S., Aguiar, T. S., Schroeder, S., Do Carmo, A. S., Carvalheiro, R., Neves, H. H. R., Padula, R. C. M., Sussai, T. S., Zavarez, L. B., Cipriano, R. S., Caminhas, M. M. T., Hambrecht, G., Colli, L., Eufemi, E., Ajmone Marsan, P., Cesana, D., Sannazaro, M., Buora, M., Morgante, M., Liu, G., Bickhart, D., Van Tassell, C. P., Sölkner, J., Sonstegard, T. S., Garcia, J. F., A PLAG1 mutation contributed to stature recovery in modern cattle, <<SCIENTIFIC REPORTS>>, 2017; 7 (1): 17140-N/A. [doi:10.1038/s41598-017-17127-1] [http://hdl.handle.net/10807/116042]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/116042
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 36
social impact