Concentrations of glutathione, uric acid and total antioxidant activity, expressed as Trolox (a water-soluble vitamin E analogue) equivalent, were measured in the saliva of healthy non-smokers and smokers before and just after smoking a single cigarette. There was no statistically significant difference between smokers and non-smokers in uric acid concentrations and total radical-trapping antioxidant capacity, but glutathione concentrations were significantly (p < 0.05) higher in smokers. Smoking of a single cigarette induced a significant reduction in glutathione concentration (p < 0.05). Salivary antioxidant power may affect individual sensitivity toward tobacco stress.
Zappacosta, B., Persichilli, S., De Sole, P., Mordente, A., Giardina, B., Effect of smoking one cigarette on antioxidant metabolites in the saliva of healthy smokers, <<ARCHIVES OF ORAL BIOLOGY>>, 1999; 44 (6): 485-488. [doi:10.1016/S0003-9969(99)00025-4] [http://hdl.handle.net/10807/10647]
Effect of smoking one cigarette on antioxidant metabolites in the saliva of healthy smokers
Zappacosta, Bruno;Persichilli, Silvia;De Sole, Pasquale;Mordente, Alvaro;Giardina, Bruno
1999
Abstract
Concentrations of glutathione, uric acid and total antioxidant activity, expressed as Trolox (a water-soluble vitamin E analogue) equivalent, were measured in the saliva of healthy non-smokers and smokers before and just after smoking a single cigarette. There was no statistically significant difference between smokers and non-smokers in uric acid concentrations and total radical-trapping antioxidant capacity, but glutathione concentrations were significantly (p < 0.05) higher in smokers. Smoking of a single cigarette induced a significant reduction in glutathione concentration (p < 0.05). Salivary antioxidant power may affect individual sensitivity toward tobacco stress.
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