https://hdl.handle.net/10807/41 Sat, 22 Aug 2026 20:04:50 GMT 2026-08-22T20:04:50Z https://hdl.handle.net/10807/344956 Titolo: Valproic acid inhibits Corticotropin Releasing Factor (CRF) synthesis and release from the rat hypothalamus in vitro: evidence for the involvement of GABAergic neurotransmission Autori: Tringali, Giuseppe; Aubry, Jean Michel; Moscianese, Katiuscia; Zamori, Claudia; Vairano, Mauro; Preziosi, Paolo; Navarra, Pierluigi; Pozzoli, Giacomo Thu, 01 Jan 2004 00:00:00 GMT https://hdl.handle.net/10807/344956 2004-01-01T00:00:00Z https://hdl.handle.net/10807/344938 Titolo: Adherence to the Mediterranean diet and incident cardiovascular outcomes among older adults Autori: Marzetti, Emanuele; Calvani, Riccardo; Rodriguez-Sanchez, Isabel; da Silva Aguiar, Samuel; Picca, Anna; Tosato, Matteo; Cacciatore, Stefano; Landi, Francesco; Coelho Júnior, Helio José Abstract: Aim: The present study examined the prospective associations between adherence to the Mediterranean (MED) diet, its individual components, and incident cardiovascular disease (CVD) among community-dwelling older adults. Methods: Data were obtained from the English Longitudinal Study of Ageing (ELSA). Participants aged ≥65 years without hypertension at baseline (Wave 9, 2018–2019) were followed through Wave 11 (2023–2024). Adherence to the MED diet was assessed using the Medi-Lite score. Incident hypertension, myocardial infarction, and stroke were identified through self-reported physician diagnoses. Logistic regression analyses were performed to examine the prospective associations between MED diet adherence, individual dietary components, and cardiovascular outcomes, adjusting for age, sex, and caloric intake. Results: A total of 338 participants (74.6 ± 6.2 years; 56.6% women) were included. During follow-up, the incidence of hypertension, myocardial infarction, and stroke was 12.4%, 2.6%, and 2.6%, respectively. No statistically significant associations were detected between overall MED diet adherence and incident hypertension (OR = 0.992, 95% CI = 0.586–1.679), myocardial infarction (OR = 1.422, 95% CI = 0.381–5.302), or stroke (OR = 0.808, 95% CI = 0.360–1.811). Likewise, none of the individual MED diet components was significantly associated with incident CVD outcomes. Conclusion: In conclusion, no statistically significant associations were detected between adherence to the MED diet and incident CVD among community-dwelling older adults in England. However, given the relatively low number of cardiovascular events, particularly myocardial infarction and stroke, these findings should be interpreted with caution. Further studies with longer follow-up periods and larger numbers of CVD events are warranted to provide more precise estimates and further clarify these associations. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/344938 2026-01-01T00:00:00Z https://hdl.handle.net/10807/344937 Titolo: Protein Homeostasis and Mitochondrial Quality Control in Neurodegeneration Autori: Di Lorenzo, Rosa; Zeidan, Rola S; Calvani, Riccardo; Pesce, Vito; Marzetti, Emanuele; Picca, Anna Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/344937 2026-01-01T00:00:00Z https://hdl.handle.net/10807/344936 Titolo: Associations between Mediterranean lifestyle and its components with clinical outcomes among community-dwelling older adults Autori: Coelho-Júnior, Hélio José; Marzetti, Emanuele Abstract: The present study examined cross-sectional and longitudinal associations between adherence to Mediterranean lifestyle (MEDLS) and health outcomes in older adults in England. We analyzed data from 565 adults aged ≥65 years in the English Longitudinal Study of Ageing. MEDLS adherence (0–24) included diet quality, physical activity, hydration, sleep, social isolation, and cooking habits. Outcomes included mobility limitations, basic (ADL) and instrumental (IADL) activities of daily living disability, walking speed, cognition, depressive symptoms, and mortality. Results indicated that higher MEDLS adherence was associated with lower ADL/IADL disability and reduced risk of functional decline. It also correlated with better cognitive performance and maintenance of processing speed, fluency, and memory, alongside fewer depressive symptoms. No associations with mortality were found. Sensitivity analysis indicated that social isolation, cooking activities, and physical activity were key contributors. In conclusion, greater MEDLS adherence relates to better physical and cognitive aging in non-MED settings. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/344936 2026-01-01T00:00:00Z