https://hdl.handle.net/10807/41 Sun, 20 Sep 2026 17:21:35 GMT 2026-09-20T17:21:35Z https://hdl.handle.net/10807/346916 Titolo: DPYD-Guided Dosing of Metronomic Capecitabine Plus Vinorelbine in Metastatic Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer: A Real-World Retrospective Study Autori: Francesco Schettini; Alexandro Membrino; Giuseppe Di Grazia; Aldo Caltavituro; Carla Strina; Manuela Milani; Antonina Impeduglia; Leda Paganini; Anna Bosi; Sara Tedoldi; Marta Gatti; Valeria Cervoni; Marzia Alberio; Mario Giuliano; Sergio Venturini; Daniele Generali Abstract: Purpose Metronomic chemotherapy with oral capecitabine + vinorelbine (Cape + VNL) provides synergistic cytostatic activity and antiangiogenic and immunomodulatory effects, potentially offering prolonged disease control with limited toxicity in HER2-negative metastatic breast cancer (MBC). However, efficacy in the real-world (RW) setting, especially in late lines, and the impact of dihydropyrimidine dehydrogenase (DPYD) polymorphisms on dose reduction and safety remain limited. Methods In this retrospective study, 200 patients with human epidermal growth factor receptor 2 (HER2)–negative MBC were treated at the ASST Cremona Hospital (2015-2023) with metronomic Cape (1000 mg twice daily, in normal metabolizers; 500 mg twice daily, in DPYD variant carriers) + VNL (20 mg/day, once daily, 5-days-on/2-days-off). All patients underwent pretreatment DPYD genotyping and dose adjustment. Treatment was administered in the second-to-fourth setting. The primary end point was time-to-next treatment or death (TNTD); secondary end points included overall survival (OS), disease control rate (DCR) ≥24 weeks, overall response rate (ORR), safety, and genotype-toxicity correlations. Results The median age was 61 years, and DPYD variants were present in 14.5% of patients; 34%, 41%, and 25% received therapy as second-, third-, and fourth-line treatment. The median TNTD was 22.0 weeks, and the OS was 64.0 weeks. The DCR was 38.5%, and the ORR was 22.0%. Efficacy was comparable between DPYD variant carriers and normal metabolizers (all P values > .05). In later lines, Eastern Cooperative Oncology Group performance status 2 and >2 metastatic sites were independent negative prognostic factors (all values P < .05). Overall, 7.5% grade 3 toxicities occurred, especially in variant carriers without dose reduction and grade 4-5 events. Conclusion These RW data suggest that metronomic Cape + VNL may represent a clinically active and manageable option in heavily pretreated HER2-negative MBC. Our findings support prospective evaluation of DPYD-guided dose individualization as a strategy to optimize the benefit-risk balance of fluoropyrimidine-based metronomic regimens. Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10807/346916 2025-01-01T00:00:00Z https://hdl.handle.net/10807/346896 Titolo: Trasformazioni del welfare e nuove prospettive sociologiche Autori: valerio corradi Abstract: The challenge of reorganizing the welfare system and the need to address new and more complex social, health, and care needs require the development of updated theoretical approaches capable of understanding the current and multifaceted dynamics within contexts characterized by the search for new structures, imbalances, but also unprecedented convergences between the different parties (State, Market, Third Sector). The social, cultural, and spatial “metamorphoses” currently underway highlight the need for new and more relevant analytical and interpretative categories to understand an increasingly complex reality. Starting from this premise, the contribution focuses on some recent theoretical interpretations of territorial welfare inspired by the theory of planetary urbanization and the perspective of the Land Urban Nexus. Finally, the possibility of rethinking the welfare system is discussed, taking into account some emerging socio-spatial aspects that bring with them new critical issues but also unprecedented opportunities.  Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10807/346896 2025-01-01T00:00:00Z https://hdl.handle.net/10807/346876 Titolo: The odd and even sets of $$\textrm{PG}(2,8)$$, up to equivalence Autori: Coolsaet, Kris; Pagani, Silvia Maria Carla; Botteldoorn, Arne Abstract: An even (resp. odd) set in a projective plane is a set of points such that every line of the plane intersects that set in an even (resp. odd) number of points. We obtained, by computer, a full classification up to equivalence of the even and odd sets of the projective plane of order 8. The generation algorithm is non-standard in that it does not incrementally add points to previously generated sets but instead starts from a family of ‘irreducible’ sets and takes subsequent symmetric differences with lines. We give geometric descriptions of the resulting sets with the largest automorphism groups, sets that can be constructed from bundles of hyperovals, linear sets, sets related to subplanes, and others. We also provide the weight enumerator of the linear code whose elements are the characteristic vectors of all even sets. We include a computer-free proof of the classification of odd and even sets up to size 13. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/346876 2026-01-01T00:00:00Z https://hdl.handle.net/10807/346836 Titolo: Differential reporting for small companies: Exploring the determinants of voluntary disclosure Autori: Daniele, Mario; Cantu, Elena Abstract: Drawing on the literature on voluntary disclosure, this study examines the disclosure choices of small companies operating under the EU accounting directive. Within the EU directive, small companies can choose a lower level of disclosure (abbreviated rules) or the higher level of disclosure required for medium and large companies (full rules). An analysis of a sample of 149,664 small private Italian companies reveals that voluntary adopters of the full rules are characterized by group affiliation and limited family control and influence. Moreover, higher levels of disclosure are observed in environments with lower social capital and in firms being targeted for mergers and acquisitions (M&A). The results are robust to alternative variable definitions, the use of propensity score matching, and the inclusion of region fixed effects. Our findings provide interesting insights into the financial reporting behavior of small companies. They also have implications for regulators engaged in the current debate on mandatory disclosures for small companies. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/346836 2026-01-01T00:00:00Z