https://hdl.handle.net/10807/222 Sat, 03 Oct 2026 11:17:48 GMT 2026-10-03T11:17:48Z https://hdl.handle.net/10807/347824 Titolo: Sugar-Sweetened Soft Drinks Consumption and Gastric Cancer: Results From the StoP Project Autori: Santucci, Claudia; Natale, Arianna; La Vecchia, Carlo; Rossi, Marta Abstract: BACKGROUND Soft drinks, and specifically sugar-sweetened non-alcoholic beverages, have been associated with metabolic disease, all-cause and cancer mortality in selected studies. However, findings for gastric cancer are inconsistent. OBJECTIVES To evaluate the association between sugar sweetened soft drinks and the risk of gastric cancer using data from the StoP Project, a global consortium of gastric cancer including 34 case-control and nested cohort studies from the Americas, Asia and Europe. METHODS We conducted a pooled analysis within the StoP Project, using harmonized data from 17 case-control and nested cohort studies with available information on soft drinks. In the present work we did not consider low-calorie sweetened beverages. Overall, 5,929 gastric cancer cases and 16,092 controls were included. Soft drink intake was categorized according to frequency of consumption. Odds ratios (OR) for gastric cancer, and the corresponding 95% confidence intervals (CI), were computed using logistic regression models adjusted for relevant confounders, including total energy intake. Pooled ORs were computed using random-effects models. For dose-risk assessment, we fitted restricted cubic spline models in a two-stage dose-risk meta-analysis. RESULTS Compared with non-consumers, the pooled OR for gastric cancer was 1.18 (95% CI 0.98–1.42) for 2 servings/week to less than 1 serving/day, 1.42 (95% CI 1.06–1.91) for 1 serv- ing/day, and 1.64 (95% CI 1.17–2.30) for more than 1 serv- ing/day. Dose-risk analysis showed a progressive increase in gastric cancer risk with higher soft drink intake: OR 1.09 (95% CI 0.92–1.30) at 0.5, 1.25 (95% CI 0.99–1.59) at 1, 1.50 (95% CI 1.13–2.00) at 1.5, and 1.81 (95% CI 1.22–2.69) at 2.0 servings/day. No significant heterogeneity was found in stratified analyses by age, sex, alcohol consumption and total energy intake. CONCLUSIONS Sugar sweetened soft drink consumption was associated with an increased risk of gastric cancer, with a dose-risk relationship. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/347824 2026-01-01T00:00:00Z https://hdl.handle.net/10807/339600 Titolo: Exploring core facets of divine forgiveness across monotheistic religions Autori: Francesca V. Danioni; Francesca Giorgia Paleari; Daniela Barni; Valentina Valtulini; Sara Eissa; Camillo Regalia Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10807/339600 2024-01-01T00:00:00Z https://hdl.handle.net/10807/337717 Titolo: Biliverdin reductase A and metabolic resilience in Alzheimer’s disease Autori: Lanzillotta, Simona; Zulli, Barbara; Sommella, Valeria; Paolozzi, Gabriele; Picca, Anna; Calvani, Riccardo; Marzetti, Emanuele; Boccardi, Virginia; Cecchetti, Roberta; Paul, Bindu D.; Mecocci, Patrizia; Tramutola, Antonella; Di Domenico, Fabio; Perluigi, Marzia; Barone, Eugenio Abstract: Alzheimer’s disease (AD) is increasingly recognized as a metabolic disorder, in which brain insulin resistance and mitochondrial dysfunction represent early pathogenic events. Biliverdin reductase A (BVRA), a pleiotropic protein with different roles as reductase, S/TS/Y kinase, scaffold and intracellular shuttle, regulates insulin signaling and mitochondrial metabolism. Although reduced BVRA has been reported in obesity, type 2 diabetes, and AD, the mechanisms linking BVRA loss to impaired brain metabolic resilience remain to be addressed. We integrated experimental models and human biomarker approaches to define the metabolic consequences of BVRA loss across aging and AD. In wild-type and BVRA knockout mice, we assessed brain insulin signaling pathways, mitochondrial function (including respirometry-based profiling), biochemical readouts of neuronal bioenergetics, and cognitive outcomes under aging and metabolic stress conditions. In parallel, we quantified BVRA in neuronal-derived extracellular vesicles (nEVs) from Ctr subjects and AD patients and tested associations with cognitive performance and AD diagnosis. BVRA loss promoted defective insulin signaling, impaired pGSK3βS9 translocation into mitochondria, and reduced activity of mitochondrial respiratory complexes, converging on energy metabolism failure and exacerbated brain insulin resistance during aging and metabolic stress. In humans, reduced BVR-A levels in nEVs were significantly associated with cognitive decline and AD diagnosis. Collectively, these data support a role for BVRA as a molecular shuttle linking insulin signaling to mitochondrial function and cellular stress-response pathways. BVRA emerges as a critical mediator of brain metabolic resilience, whose loss accelerates insulin resistance, mitochondrial dysfunction, and cognitive deterioration. Targeting BVRA–dependent pathways may enable earlier diagnosis and more personalized therapeutic strategies in AD and related metabolic conditions. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/337717 2026-01-01T00:00:00Z https://hdl.handle.net/10807/337137 Titolo: Emotionally and practically supporting parents during young adulthood Autori: Danioni, F; Regalia, C; Ranieri, S; Barni, D Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/10807/337137 2024-01-01T00:00:00Z