https://hdl.handle.net/10807/95494 2026-06-24T01:50:27Z https://hdl.handle.net/10807/340119 Titolo: Opportunistic Salpingectomy for Prevention of Tubo-Ovarian Carcinoma: The European Society of Gynaecological Oncology Consensus Statements Autori: Piek J. M.; Schauwaert J.; Ellis L. B.; Zapardiel I.; Planchamp F.; Koblos K.; Kacperczyk-Bartnik J.; Bowden S. J.; El Hajj H.; Grigore M.; Steenbeek M. P.; Bizzarri N.; Kyrgiou M.; Gultekin M. Abstract: Importance: The fallopian tube epithelium has been demonstrated to be an important source of tubo-ovarian carcinoma. Therefore, removal of the fallopian tubes during unrelated pelvic or abdominal surgery (opportunistic salpingectomy) can potentially lower future ovarian cancer risk. Objectives: To assess current evidence on the efficacy, risks, and long-term outcomes of opportunistic salpingectomy and to develop consensus statements for the European Society of Gynaecological Oncology. Evidence Review: An international working group of 14 individuals including a patient representative was formed to develop consensus statements on opportunistic salpingectomy. The MEDLINE database was used to conduct a literature review of English-language studies from January 1, 2000, through March 1, 2025, evaluating opportunistic salpingectomy for reduction of tubo-ovarian carcinoma, complication rates, additional surgical time, and impact on ovarian function. Statements were subsequently drafted collaboratively based on the review of the literature and adapted in an iterative process in conference call meetings with opportunity for anonymous and nonanonymous feedback. The anonymous voting was binary (agree/disagree) for each potential statement. Final statements reached consensus with more than 75% agreement. Findings: In the literature review, 230 studies were identified, of which 129 were deemed relevant to consensus statement development. Consensus was achieved on 18 statements, with grades of recommendation ranging from B to D and levels of evidence from II to V. Opportunistic salpingectomy is significantly associated with a lower risk of subsequent tubo-ovarian carcinoma, with no adverse short-term impact on ovarian function. The procedure appears safe across surgical approaches, with little additional operative time. Existing evidence does not indicate harm to ovarian function or premature menopause, although long-term evidence is not available. Salpingectomy is feasible during both gynecological and nongynecological procedures and should be considered in women undergoing gynecological surgery and, where possible, in women undergoing selected nongynecological pelvic or abdominal surgeries. Conclusions and Relevance: Existing evidence demonstrates that opportunistic salpingectomy is significantly associated with a lower risk of developing tubo-ovarian carcinoma. Clinicians should include this prevention intervention in preoperative counseling of eligible women. 2026-01-01T00:00:00Z https://hdl.handle.net/10807/339779 Titolo: Oltre le sbarre: Il «Metodo Cec» dell’associazione papa Giovanni XXIII nella realtà riminese a partire da una ricerca etnografica Autori: PETRONI LAURA Abstract: Nel presente articolo vengono riportati i risultati di una ricerca etnografica volta a conoscere l’esperienza CEC (Comunità Educante con i Carcerati), con particolare riferimento alla prima fase di questo metodo. Giorgio Pieri, membro dell’Associazione Papa Giovanni XXIII, ispirandosi al modello APAC nato in Brasile, ha fondato il metodo CEC che si prepone, a partire da alcuni principi ispiratori e dall’utilizzo di diversi strumenti, di accompagnare chi ha commesso un reato ad avviare un cammino di cambiamento. La ricerca etnografica è stata condotta, nel mese di ottobre 2021, all’interno di una comunità — sita a Rimini — che si occupa della prima fase del metodo CEC: quella di accoglienza. L’osservazione partecipante, la raccolta di note etnografiche e l’intervista semi-strutturata, rivolta al fondatore a conclusione del mese di permanenza in struttura, hanno consentito di ottenere un materiale denso di informazioni che è stato poi sottoposto ad analisi tematica. I dati ottenuti sono stati -infine- riletti attraverso le lenti del Relational Social Work: questo lavoro ha permesso di individuare alcune linee guida e principi, che a partire dall’esperienza CEC, possono essere utili a tendere al mandato rieducativo sancito nella Costituzione. 2025-01-01T00:00:00Z https://hdl.handle.net/10807/339667 Titolo: Time course of brain-derived neurotrophic factor release following acute exercise: a comparative study in young and middle-aged adults. Autori: Marano L; Tommasini E; Missaglia S; Vago P; Pecci C; Rampinini E; Bosio A; Morelli A; Tavian D. Abstract: Purpose: Brain Derived Neurotrophic Factor (BDNF) is a crucial neurotrophin involved in memory, learning and neural plasticity. Its levels can be significantly influenced by several exogenous stimuli such as physical exercise (PE)1. For this reason, the effect of PE on BDNF release has been previously studied in physiological and pathological conditions2,3. This study aimed to evaluate the BDNF time course in two age groups of healthy males after an incremental exercise, as this comparison has not yet been made. Methods: Twenty young adults (YA: 24.7±3.6 yrs; percentage of fat mass (%FM): 11.1±5.4%; peak oxygen uptake (V̇O2peak): 49.7±9.9 ml/kg/min) and 12 middle-aged adults (MA: 54.6±5.7 yrs; %FM: 16.7±6.5%; V̇O2peak: 44.8±5.1 ml/kg/min) were enrolled. Participants underwent a cycling ramp V̇O2max test till exhaustion, while constantly measuring gas exchange using a metabolimeter. Peripheral blood samples were collected at baseline (T0), 15 min (T1), and 24 h (T2) after the exercise test. Serum BDNF (sBDNF) levels were measured using an ELISA kit. Wilcoxon signed rank and Mann Whitney U test were used to analyse the data. Results were considered significant when p<0.05. Results: sBDNF levels did not show significant changes from T0 to T1 for both YA and MA groups. Instead, a significant sBDNF increase was observed between T0 (YA T0: 13.3±1.69 ng/ml and MA T0: 12.7±0.9 ng/ml) and T2 for both groups (YA T2: 15.5±3.5 ng/ml, p<0.001; MA T2: 14.4±3 ng/ml; p<0.05). No statistical differences in sBDNF levels were found between groups in all time points, neither for absolute values nor for percentage changes. Conclusions: Our study represents a pioneering investigation that explored the impact of age on sBDNF release following acute strenuous exercise within a substantial cohort of healthy males. We detected a significant increase of sBDNF at 24 h post exercise both in YA and MA with no differences between the two groups. These findings confirm the importance of acute exercise to stimulate BDNF release also in MA people and emphasize the pivotal role of PE in promoting neurogenesis and plasticity across the entire lifespan. 2024-01-01T00:00:00Z https://hdl.handle.net/10807/339663 Titolo: Beta-endorphin levels following acute physical exercise in young and middle-aged adults. Autori: Tommasini E; Marano L; Vago P; Pecci C; Rampinini E; Bosio A; Morelli A; Tavian D; Missaglia S 2024-01-01T00:00:00Z