IRIS Tipologia:
https://hdl.handle.net/10807/200
2024-03-28T05:23:10ZAsymptotic decay of solutions for sublinear fractional Choquard equations
https://hdl.handle.net/10807/268559
Titolo: Asymptotic decay of solutions for sublinear fractional Choquard equations
Autori: Gallo, Marco
Abstract: Goal of this paper is to study the asymptotic behaviour of the solutions of the following doubly nonlocal equation (−Δ)su+μu=(Iα∗F(u))f(u)onRNwhere s∈(0,1), N≥2, α∈(0,N), μ>0, Iα denotes the Riesz potential and F(t)=∫0tf(τ)dτ is a general nonlinearity with a sublinear growth in the origin. The found decay is of polynomial type, with a rate possibly slower than [Formula presented], and it complements the decays obtained in the linear and superlinear cases in Cingolani et al. (2022); D'Avenia et al. (2015). Differently from the local case s=1 in Moroz and Van Schaftingen (2013), new phenomena arise connected to a new “s-sublinear” threshold that we detect on the growth of f. To gain the result we in particular prove a Chain Rule type inequality in the fractional setting, suitable for concave powers.2024-01-01T00:00:00ZChronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS)
https://hdl.handle.net/10807/268537
Titolo: Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS)
Autori: Niemeyer, C M; Arico, M; Basso, G; Biondi, A; Cantu Rajnoldi, A; Creutzig, U; Haas, O; Harbott, J; Hasle, H; Kerndrup, G; Locatelli, F; Mann, G; Stollmann-Gibbels, B; van't Veer-Korthof, E T; van Wering, E; Zimmermann, M1997-01-01T00:00:00ZTransplant of bone marrow and cord blood hematopoietic stem cells in pediatric practice, revisited according to the fundamental principles of bioethics
https://hdl.handle.net/10807/268536
Titolo: Transplant of bone marrow and cord blood hematopoietic stem cells in pediatric practice, revisited according to the fundamental principles of bioethics
Autori: Burgio, G R; Locatelli, F
Abstract: The two most widely used sources of hematopoietic stem cells for allogeneic transplants in pediatric practice are bone marrow (BM) and cord blood (CB), While bone marrow transplantation (BMT) is reaching its 30th year of application, human umbilical cord blood transplantation (HUCBT) is approaching its 10th, Although these procedures have basically the same purpose, a number of biological differences distinguish them, In particular, the intrinsically limited quantity of CB stem cells and their immunological naivete confer peculiar characteristics to these hematopoietic progenitors, From a bioethical point of view, the problems which have repeatedly been raised when the BM donor is a child are well-known, Different but no less important ethical problems are raised when one considers HUCBT; in this regard the most important issues are the easier propensity of programming a CB donor in comparison with a BM donor (clearly due to the shorter time interval needed to collect the hematopoietic progenitors); the in utero HLA-typing; the implication of employing 'blood belonging to a neonate' for a third party; the need to perform a number of investigations both on the CB of the donor and on the mother and the implications that the discovery of disease may have for them, but also the need to establish banks for storing CB, with the accompanying administration and management problems, All these different aspects of UCBT will be discussed in the light of the four fundamental and traditional principles of bioethics, namely autonomy, nonmaleficence, beneficence and justice.1997-01-01T00:00:00ZOutcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group
https://hdl.handle.net/10807/268535
Titolo: Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group
Autori: Gluckman, E; Rocha, V; Boyer-Chammard, A; Locatelli, F; Arcese, W; Pasquini, R; Ortega, J; Souillet, G; Ferreira, E; Laporte, J P; Fernandez, M; Chastang, C
Abstract: Background Cord-blood banks have increased the use of cord-blood transplantation in patients with hematologic disorders. We have established a registry containing information on the outcome of cord-blood transplantation.Methods We sent questionnaires to 45 transplantation centers for information on patients receiving cord-blood transplants from 1988 to 1996. Reports on 143 transplantations, performed at 45 centers, were studied, and the responses were analyzed separately according to whether the donor was related or unrelated to the recipient.Results Among 78 recipients of cord blood from related donors, the Kaplan-Meier estimate of survival at one year was 63 percent. Younger age, lower weight, transplants from HLA-identical donors, and cytomegalovirus-negative serologic results in the recipient were favorable prognostic factors. Graft-versus-host disease of at least grade II occurred at estimated rates of 9 percent in 60 recipients of HLA-matched cord blood and 50 percent in 18 recipients of HLA-mismatched cord blood. Neutrophil engraftment was associated with an age of less than six years (P = 0.02) and a weight of less than 20 kg (P = 0.02), and it occurred in 85 percent of patients receiving 37 million or more nucleated cells per kilogram of body weight. Among 65 patients who received cord blood from unrelated donors, the Kaplan-Meier estimate of survival at one year was 29 percent. Cytomegalovirus-negative serologic status in these recipients was associated with improved survival (P = 0.03) and was the most important predictor of graft-versus-host disease (P = 0.04). Neutrophil recovery occurred in 94 percent of the patients who received 37 million or more nucleated cells per kilogram from unrelated donors.Conclusions Cord blood is a feasible alternative source of hematopoietic stem cells for pediatric and some adult patients with major hematologic disorders, particularly if the donor and the recipient are related. (C) 1997, Massachusetts Medical Society.1997-01-01T00:00:00Z