https://hdl.handle.net/10807/95494 2026-04-23T03:17:52Z 2026-04-23T03:17:52Z https://hdl.handle.net/10807/334137 2026-04-23T01:11:09Z 2025-01-01T00:00:00Z

Titolo: Perceptions, Expectations, and Adherence in Interstitial Lung Disease: Insights from a Multicentre Mixed-Methods Study Autori: Volpato, Eleonora; Buscemi, Agata A. M. D.; De Petro, Claudia; Silani, Margherita S; Mantero, Marco; Blasi, Francesco; Banfi, Paolo I Abstract: BACKGROUND AND AIMS: Interstitial lung diseases (ILD) are a heterogeneous group of chronic disorders leading to progressive lung damage and disability. While their physiological impact is well documented, the effects on quality of life, fatigue, and daily functioning remain less clear. Understanding how patients perceive their illness and treatments may offer new insights into adherence and self-management.1 This study examined whether illness perceptions and expectations influence adherence to antifibrotic therapy, oxygen therapy, and non-invasive ventilation. It also explored emotional responses, perceived barriers, and perceived benefits associated with illness and treatment in individualswith ILD.2 MATERIALS AND METHODS: This multicentre, prospective, mixed-methods study was conducted by IRCCS Fondazione Don Carlo Gnocchi, Milan, in collaboration with the Ospedale Maggiore Policlinico of Milan, Italy. Respiratory function, comorbidities, and treatment adherence were assessed at baseline (T0), 6 months (T1), and 12 months (T2). Psychological measures included the Brief Illness Perception Questionnaire (B-IPQ), Beliefs about Medication Questionnaire (BMQ), Medication Adherence Rating Scale-5I (MARS-5I), and Illness Cognition Questionnaire (ICQ). In parallel, semi-structured interviews were analysed using Interpretative Phenomenological Analysis to capture patients’ lived experiences and meanings attached to illness and treatment. RESULTS: A total of 125 adults with ILD were enrolled (median age: 73 years; 72% male). The present report focuses on preliminary data from 48 participants who completed at least one follow-up assessment. Full adherence was observed in 61.5% of patients for antifibrotic therapy and 68.0% for oxygen therapy. A significant negative correlation emerged between diffusing capacity for carbon monoxide and antifibrotic adherence (r=−0.571; p<0.001). No significant linear associations were detected between illness perceptions, medication beliefs, and adherence scores. However, exploratory analyses suggested a non-linear trend: patients with moderate illness perception scores showed the highest adherence across time, whereas those with very low or very high perceived illness threat tended to adhere less. From a cognitive perspective, ICQ scores remained relatively stable, but higher ‘Acceptance’ and ‘Perceived Benefits’ scores were observed in participants with sustained adherence. The qualitative strand identified four major themes describing patients’ lived experiences: 1) illness perception and uncertainty; 2) illness and treatment knowledge; 3) relationship with therapy and healthcare professionals; and 4) expectations of the future. Together, these findings suggest that adherence is not merely a behavioural outcome, but a dynamic process shaped by how patients understand and emotionally integratetheir illness.3,4 CONCLUSION: Adherence in ILD appears to be influenced by both medical and psychological factors, with illness perception profiles and perceived benefits being particularly relevant. Extreme perceptions, either minimising or catastrophising illness, may undermine long-term engagement with therapy. Strengthening education, emotional support, and individualised communication could help realign patients’ beliefs and expectations, thereby promoting adherence and improving quality of life.1 Future studies with the full sample will clarify whether specific cognitive–emotional patterns predict adherence trajectories, and may inform tailored psychosocial interventions in ILD care.

2025-01-01T00:00:00Z https://hdl.handle.net/10807/331816 2026-03-08T01:51:11Z 2026-01-01T00:00:00Z

Titolo: The Human in the Loop: Scaling a Generational-Defining LegalTech Company from Milan to the World. In Conversation with Martina Domenicali, Co-Founder and CRO, LEXROOM Autori: pezzuto, ivo Abstract: This article, written by Dr. Ivo Pezzuto as part of the Forward Thinkers’ Talks Series, features an in-depth conversation with Martina Domenicali, Co-Founder and CRO of Lexroom, and examines a defining question reshaping Europe’s LegalTech landscape: can hyper-specialized, jurisdiction-native AI outperform horizontally scaled, general-purpose models in high-liability professions? In February 2026, the company surpassed €10 million in Annual Recurring Revenue (ARR)—by curating over six million localized legal documents to build a data-first, deeply verifiable AI platform tailored to civil-law systems—an inflection point that places it among Europe’s fastest-scaling AI ventures. The article investigates how depth-driven localization creates structural defensibility and how governance-by-design, source traceability, and human-in-the-loop workflows redefine professional practice. Evidence shows that precision and accountability—rather than generic LLM capability—drive sustained adoption, reflected in 93% retention and strong Net Revenue Retention. Contrasted with Anthropic’s horizontal plugin model, Lexroom’s approach signals a broader theoretical shift: in regulated domains, competitive advantage stems from embedding AI within institutional authority and workflow infrastructure. The implication for scholars and executives is clear—durable AI leadership will be secured not by scale alone, but by context-embedded intelligence that transforms technology into a trusted professional backbone.

2026-01-01T00:00:00Z https://hdl.handle.net/10807/330474 2026-04-16T23:09:54Z 2025-01-01T00:00:00Z

Titolo: Competenze organizzative e sostenibilità nella leadership scolastica Autori: Zane E.; Righettini C.; Mazzoli S. Abstract: La crescente attenzione verso la sostenibilità sollecita una riflessione sui modelli di governance scolastica e sul ruolo del dirigente, chiamato a integrare competenze manageriali, sensibilità ecologica e capacità di innovazione organizzativa. L’introduzione del nuovo sistema di valutazione dirigenziale del 2025 si inserisce in questo scenario, aprendo prospettive di ridefinizione delle competenze richieste. Le cosiddette green competences possono costituire un elemento di trasformazione, incidendo sia sulla gestione delle risorse materiali ed energetiche, sia sulla progettazione educativa partecipata e sulla formazione in servizio dei docenti. Un approccio orientato alla sostenibilità sembra inoltre favorire percorsi didattici innovativi, capaci di sviluppare negli studenti consapevolezza critica e competenze trasversali in materia ambientale.

2025-01-01T00:00:00Z https://hdl.handle.net/10807/330278 2026-04-15T23:13:43Z 2025-01-01T00:00:00Z

Titolo: Impact of biological sex and motor reserve on recovery following motor telerehabilitation in Parkinson’s disease Autori: Francesca Baglio; Sara Isernia; Monia Cabinio; Federica Rossetto; Francesca Borgnis; Chiara Pagliari; Alice Pirastru; Mario Clerici; Valeria Blasi Abstract: Background and aims Biological sex differences in Parkinson’s Disease (PD) remain an underexplored topic, with early studies identifying distinct clinical phenotypes. Typically, treatment outcomes are assessed through the motor reserve paradigm rather than sex-related mechanisms. This study examined both factors in response to a structured telerehabilitation program. Methods Data of the present study were collected within the MNESYS project (A multiscale integrated approach to the study of the nervous system in health and disease . PROJECT ID: PE00000006. CUP: B43D22000650006 . Avviso: Decreto Direttoriale n. 341 del 15 marzo 2022 Proposte di intervento per la creazione di “Partenariati estesi alle università, ai centri di ricerca, alle aziende per il finanziamento di progetti di ricerca di base” nell’ambito del Piano Nazionale di Ripresa e Resilienza). Forty individuals with early PD (21 males) underwent a four-month intensive rehabilitation program, with baseline diffusionweighted MR imaging and motor assessments pre- and postintervention. Patients were classified as responders or non-responders based on the Minimal Clinically Important Difference of the 6-Minute Walk Test. A motor reserve index was calculated using a residuals-based approach incorporating nigrostriatal degeneration, Hoehn & Yahr score, age, and education. Results No sex differences were found in baseline demographics or clinical profiles. However, chi-squared analysis indicated that males responded more favorably to treatment (81 % vs. 42 % in females), with a 54 % higher probability of gait function improvement. Conclusions Motor reserve significantly influenced treatment response, even in individuals with low motor reserve, regardless of sex. These findings highlight the importance of considering sex-related mechanisms in rehabilitation outcomes for PD patients.

2025-01-01T00:00:00Z