IRIS Tipologia:https://hdl.handle.net/10807/2222026-06-22T22:08:04Z2026-06-22T22:08:04ZExploring core facets of divine forgiveness across monotheistic religionshttps://hdl.handle.net/10807/3396002026-06-19T23:14:06Z2024-01-01T00:00:00ZTitolo: Exploring core facets of divine forgiveness across monotheistic religions
Autori: Francesca V. Danioni; Francesca Giorgia Paleari; Daniela Barni; Valentina Valtulini; Sara Eissa; Camillo Regalia2024-01-01T00:00:00ZBiliverdin reductase A and metabolic resilience in Alzheimer’s diseasehttps://hdl.handle.net/10807/3377172026-06-04T23:42:52Z2026-01-01T00:00:00ZTitolo: Biliverdin reductase A and metabolic resilience in Alzheimer’s disease
Autori: Lanzillotta, Simona; Zulli, Barbara; Sommella, Valeria; Paolozzi, Gabriele; Picca, Anna; Calvani, Riccardo; Marzetti, Emanuele; Boccardi, Virginia; Cecchetti, Roberta; Paul, Bindu D.; Mecocci, Patrizia; Tramutola, Antonella; Di Domenico, Fabio; Perluigi, Marzia; Barone, Eugenio
Abstract: Alzheimer’s disease (AD) is increasingly recognized as a metabolic disorder, in which brain insulin resistance and mitochondrial dysfunction represent early pathogenic events. Biliverdin reductase A (BVRA), a pleiotropic protein with different roles as reductase, S/TS/Y kinase, scaffold and intracellular shuttle, regulates insulin signaling and mitochondrial metabolism. Although reduced BVRA has been reported in obesity, type 2 diabetes, and AD, the mechanisms linking BVRA loss to impaired brain metabolic resilience remain to be addressed. We integrated experimental models and human biomarker approaches to define the metabolic consequences of BVRA loss across aging and AD. In wild-type and BVRA knockout mice, we assessed brain insulin signaling pathways, mitochondrial function (including respirometry-based profiling), biochemical readouts of neuronal bioenergetics, and cognitive outcomes under aging and metabolic stress conditions. In parallel, we quantified BVRA in neuronal-derived extracellular vesicles (nEVs) from Ctr subjects and AD patients and tested associations with cognitive performance and AD diagnosis. BVRA loss promoted defective insulin signaling, impaired pGSK3βS9 translocation into mitochondria, and reduced activity of mitochondrial respiratory complexes, converging on energy metabolism failure and exacerbated brain insulin resistance during aging and metabolic stress. In humans, reduced BVR-A levels in nEVs were significantly associated with cognitive decline and AD diagnosis. Collectively, these data support a role for BVRA as a molecular shuttle linking insulin signaling to mitochondrial function and cellular stress-response pathways. BVRA emerges as a critical mediator of brain metabolic resilience, whose loss accelerates insulin resistance, mitochondrial dysfunction, and cognitive deterioration. Targeting BVRA–dependent pathways may enable earlier diagnosis and more personalized therapeutic strategies in AD and related metabolic conditions.2026-01-01T00:00:00ZEmotionally and practically supporting parents during young adulthoodhttps://hdl.handle.net/10807/3371372026-06-12T17:06:28Z2024-01-01T00:00:00ZTitolo: Emotionally and practically supporting parents during young adulthood
Autori: Danioni, F; Regalia, C; Ranieri, S; Barni, D2024-01-01T00:00:00ZAssociation between Life's Essential 8 and Self-reported Walking Difficulty in Community-dwelling Middle-aged and Older Adultshttps://hdl.handle.net/10807/3336562026-06-13T18:05:39Z2025-01-01T00:00:00ZTitolo: Association between Life's Essential 8 and Self-reported Walking Difficulty in Community-dwelling Middle-aged and Older Adults
Autori: Cacciatore, S; Calvani, R; Tosato, M; Marzetti, E; Landi, F
Abstract: Background: Self-reported walking difficulty (SrWD) is a key indicator of health and functional decline across the lifespan. Life’s Essential 8 (LE8) evaluates cardiovascular health through metrics including diet, physical activity (PA), body mass index (BMI), blood pressure (BP), cholesterol, glucose, nicotine exposure, and sleep. This retrospective cross-sectional study explores the association between SrWD and LE8 score in community-dwelling middle-aged (40–65 years) and older adults (≥ 65 years) from the Longevity Check-up (Lookup) 8+ cohort. Methods: Lookup 8+ is an ongoing initiative started in June 2015, conducted in unconventional settings across Italy (e.g., malls, exhibitions) to promote healthy lifestyles in the general population. SrWD was assessed with a single question: “Do you have any difficulty in walking 400 meters?”. LE8 components were evaluated using a diet and lifestyle questionnaire, and a brief assessment including point-of-care serum cholesterol and blood glucose testing.
Results: By October 2024, 7064 participants aged ≥40 years were enrolled (mean age 60.1 ± 11.2, 33.7% aged ≥ 65 years; 53.5% women; mean LE8 score 65.0 ± 12.7). They were grouped into low (n = 863), moderate (n = 5288), and high (n = 913) LE8 score. The low group was older, had lower muscle mass, and greater dynapenia. SrWD was highest in the low group (31.4%), followed by moderate (14.1%) and high (4.8%) (p < 0.001). 10.3% of those aged 40–65 reported SrWD, increasing across age groups (p for trend < 0.001). Logistic regression revealed an inverse association between SrWD and LE8 scores, with moderate and high groups having 64% and 89% lower odds of SrWD than the low group, respectively Random forest identified PA, BP, and BMI as top predictors overall and for ages 40–65, with diet replacing BMI in those ≥65. Logistic regression showed PA, BMI, sleep, and diet (only ≥ 65 years) were significantly linked to SrWD, while BP, cholesterol, glucose, and smoking showed weaker or no associations after adjustments. Conclusions: LE8 score was inversely associated with SrWD in middle-aged and older adults. These findings highlight the importance of cardiovascular health and prevention to maintain mobility and independence.2025-01-01T00:00:00Z