IRIS Tipologia:https://hdl.handle.net/10807/2002024-03-28T16:05:57Z2024-03-28T16:05:57ZBuilding a global consensus approach to chordoma: a position paper from the medical and patient communityhttps://hdl.handle.net/10807/2688242024-03-28T16:05:28Z2015-01-01T00:00:00ZTitolo: Building a global consensus approach to chordoma: a position paper from the medical and patient community
Autori: Stacchiotti S. Ares C; Blay JY; Bollè S; Boriani S; Capanna R; Casali PG; Debus J; DeLaney TF; Doglietto F; Flanagan AM; Fossati P; Froelich S; Gelderblom H; Grimer R; Gronchi A; Haas RLM; Hohenberger P; Hornicek FJ; Jeys L; Kasper B; Keulen H; Krengli M; Leithner A; Martin-Broto J; Morosi C; Nicolai P; Norum OJ; Peul WC; Pilotti S; Radaelli S; Rutkowski P; Scheipl S; Tamborini E; Torri V; Uhl M; Vanel D; Vleggeert-Lankamp C; Weber DC; Sommer J
Abstract: Chordomas are very rare bone malignant tumours that have had a shortage of effective treatments for a long time. New treatments are now available for both the local and the metastatic phase of the disease, but the degree of uncertainty in selecting the most appropriate treatment remains high and their adoption remains inconsistent across the world, resulting in suboptimum outcomes for many patients. In December, 2013, the European Society for Medical Oncology (ESMO) convened a consensus meeting to update its clinical practice guidelines on sarcomas. ESMO also hosted a parallel consensus meeting on chordoma that included more than 40 chordoma experts from several disciplines and from both sides of the Atlantic, with the contribution and sponsorship of the Chordoma Foundation, a global patient advocacy group. The consensus reached at that meeting is shown in this position paper.2015-01-01T00:00:00ZRobotic Transnasal Endoscopic Skull Base Surgery: Systematic Review of the Literature and Report of a Novel Prototype for a Hybrid System (Brescia Endoscope Assistant Robotic Holder)https://hdl.handle.net/10807/2688232024-03-28T16:00:47Z2017-01-01T00:00:00ZTitolo: Robotic Transnasal Endoscopic Skull Base Surgery: Systematic Review of the Literature and Report of a Novel Prototype for a Hybrid System (Brescia Endoscope Assistant Robotic Holder)
Autori: Bolzoni Villaret A.; Doglietto F.; Carobbio A.; Schreiber A.; Panni C.; Piantoni E.; Guida G.; Fontanella M. M.; Nicolai P.; Cassinis R.
Abstract: Background Although robotics has already been applied to several surgical fields, available systems are not designed for endoscopic skull base surgery (ESBS). New conception prototypes have been recently described for ESBS. The aim of this study was to provide a systematic literature review of robotics for ESBS and describe a novel prototype developed at the University of Brescia. Methods PubMed and Scopus databases were searched using a combination of terms, including Robotics OR Robot and Surgery OR Otolaryngology OR Skull Base OR Holder. The retrieved papers were analyzed, recording the following features: interface, tools under robotic control, force feedback, safety systems, setup time, and operative time. A novel hybrid robotic system has been developed and tested in a preclinical setting at the University of Brescia, using an industrial manipulator and readily available off-the-shelf components. Results A total of 11 robotic prototypes for ESBS were identified. Almost all prototypes present a difficult emergency management as one of the main limits. The Brescia Endoscope Assistant Robotic holder has proven the feasibility of an intuitive robotic movement, using the surgeon's head position: a 6 degree of freedom sensor was used and 2 light sources were added to glasses that were therefore recognized by a commercially available sensor. Conclusions Robotic system prototypes designed for ESBS and reported in the literature still present significant technical limitations. Hybrid robot assistance has a huge potential and might soon be feasible in ESBS.2017-01-01T00:00:00ZHigh-Definition 3-Dimensional Exoscope for 5-ALA Glioma Surgery: 3-Dimensional Operative Videohttps://hdl.handle.net/10807/2688212024-03-28T15:59:24Z2020-01-01T00:00:00ZTitolo: High-Definition 3-Dimensional Exoscope for 5-ALA Glioma Surgery: 3-Dimensional Operative Video
Autori: Doglietto F.; Belotti F.; Panciani P.; Poliani P. L.; Fontanella M. M.
Abstract: High-Definition 3-Dimensional Exoscope for 5-ALA Glioma Surgery: 3-Dimensional Operative Video2020-01-01T00:00:00ZPlurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Reviewhttps://hdl.handle.net/10807/2688202024-03-28T15:57:28Z2018-01-01T00:00:00ZTitolo: Plurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Review
Autori: Roca E.; Mattogno P. P.; Porcelli T.; Poliani L.; Belotti F.; Schreiber A.; Maffezzoni F.; Fontanella M. M.; Doglietto F.
Abstract: Background: Plurihormonal adenomas (PHAs) represent 10%–15% of all functioning pituitary adenomas. The most frequent hormonal associations are with prolactin and growth hormone (GH). Here we describe a rare case of functional adrenocorticotropic hormone (ACTH) and GH microadenoma and report our findings from a systematic literature review of PHA. Methods: We searched PubMed using the terms “plurihormonal pituitary adenoma,” “ACTH GH pituitary adenoma,” and “acromegaly AND Cushing's disease”. In the 17 articles that were selected for literature review, only 20% (4/20) of patients presented with clinical signs of both diseases. Histologically, 19 were pituitary adenomas composed of two distinct cell populations, while only in 1 case was there evidence of a single cell producing both ACTH and GH. In the case reported here, a 60-year-old woman was incidentally diagnosed with a pituitary microadenoma. Endocrine assessment documented increased levels of insulin-like growth factor 1 and GH; ACTH and cortisol values were within normal ranges. Echocardiography documented ventricular hypertrophy. Because of clinical and biochemical evidence of acromegaly, surgery was recommended. Postoperatively, hormonal replacement therapy was started because of adrenal insufficiency. Her antihypertensive therapy was discontinued due to evidence of normal blood pressure values. Histological examination revealed an ACTH-GH PHA with 2 distinct populations of secreting cells. At 3-year follow-up, the patient showed stable clinical remission and was no longer receiving hormonal replacement therapy. Conclusions: This is an additional case to the 20 previously reported cases of ACTH-GH PHA. Awareness of this relatively rare entity is clinically relevant. The cytogenesis of ACTH-GH PHA remains a matter of debate, and several hypotheses have been postulated.2018-01-01T00:00:00Z